Development of a Nanometer Scale Wire Using G-DNA

G-DNA is a quadruple helix composed of guanine tetrads called G-quartets, and is stabilized by metal cation coordination. The purpose of this study is to create a nanometer scale wire using G-DNA as a scaffold element. Tet1.5 [GGGGTTGGGG] and amino and thiol modified sequences will be allowed to self-assemble into long strands of G-DNA called G-wires. The G-wires will be doped with gold particles via biotin streptavidin interactions. The gold particles tethered to the G-wire scaffold will nucleate the deposition of silver particles, forming a nanometer scale wire. Atomic force microscopy, AFM, will provide images of the self-assembled nanoscale structures.